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News Updates: Research

Otonomy Enrolls First Meniere's Disease Patients in OTO-104 Multiple-Dose Safety Study

Posted by Kerrie Denner

Otonomy, Inc. (Nasdaq:OTIC), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapeutics for diseases and disorders of the inner and middle ear, today announced the enrollment of the first patients in a multiple-dose safety study of OTO-104 initiated in the United Kingdom (U.K.) in patients with Ménière's disease.

Researchers explore gene expression in normal vestibular nerves, vestibular schwannomas

Posted by Kerrie Denner

Researchers from the University of Toronto, directed by Drs. Gelareh Zadeh and Boris Krischek, investigated gene expression in normal vestibular nerves and vestibular schwannomas (VSs). Two important discoveries were made: 1) there is negligible difference between VSs that sporadically occur and those commonly associated with neurofibromatosis Type 2 (NF2), a genetic disorder; and 2) the overexpressed PI3K/AKT/mTOR signaling pathway in these tumors may be an excellent therapeutic target.

New Treatment Successful for Rare and Disabling Movement Disorder, the Mal de Debarquement Syndrome (MdDS)

Posted by Kerrie Denner

People who suffer from a rare illness, the Mal de Debarquement Syndrome (MdDS), now have a chance for full recovery thanks to treatment developed by researchers at the Icahn School of Medicine at Mount Sinai.  Their findings were published online in the July issue of Frontiers in Neurology.  

Genetic Studies Lead the Way to Understanding EVA, a Childhood Hearing Disorder

Posted by Kerrie Denner

Andrew J. Griffith, M.D., Ph.D., scientific director of the NIDCD; Credit: Chris Gunn

By Kirstie Saltsman, Ph.D.

For several decades, researchers at the National Institute on Deafness and Other Communication Disorders (NIDCD) have been leading an effort to understand the genetic underpinnings of enlarged vestibular aqueducts (EVA), a condition associated with early hearing loss in children, and in some cases, thyroid problems in the teenage years.

New research probes inner ear disease

Posted by Kerrie Denner

A new study has shed light on the factors likely to lead to the development of a rare condition affecting the inner ear.

In the most comprehensive study of Ménière’s Disease to date, researchers at the European Centre have been able to suggest what goes wrong in the body when people develop the disease, and provide an insight into factors that lead to its development.

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