Share

Clinical Trials Recruiting Patients

Vestibular Research Studies

Below are clinical studies that are currently recruiting research study participants.

*If you are a VEDA professional member and would like to recruit participants for your research study, click here to submit your request.

Title: EquiCue™ Intraoral Electronic Balance Aid for Patients with Vestibular Imbalance

Objective: To study how alternative sensory feedback on the palate can be used to improve balance for patients with vestibular loss.

Participant Information: This initial study investigates use of a hidden and noninvasive balance device EquiCue™ V1 for vestibular substitution.  EquiCue™ V1 is an intraoral electronic balance aid custom made, removable, and entirely worn inside the oral cavity like a dental retainer. It provides in-situ sensory feedback of head tilting and motion on the palatal surface. Patients use the alternative feedback for head orientation and perception of self-motion which further facilitate control of postural stability.

Inclusion criteria:

  1. Adults between ages of 18-85.
  2. Bilateral/unilateral vestibular loss with chronic imbalance primarily due to vestibular dysfunction.
Study Status: Recruiting
Study Results Expected: Mar. 15, 2017
Sponsor: Innervo Technology LLC
Collaborators: Blue Ridge Physical Therapy (for Kansas City region)
Contact Info: Mike Woodward or Kelli Knight at (816)795-6999
Location: 4900 S. Arrowhead Dr. Ste.B, Independence, MO 64055

TITLE: Multichannel vestibular implant early feasibility study


Objective: Study the safety and effectiveness of an implanted inner ear stimulator system designed to restore vestibular sensation.


Participant Information: Please see the Vestibular Implant Study link at www.jhu.edu/vnel for details regarding study inclusion criteria and how to apply to participate. Five subjects will be implanted in the first study. Potential candidates should have bilateral loss of vestibular sensation of at least one year duration, inadequate recovery despite adequate vestibular rehab, good hearing in at least one ear, prior testing (including audiogram, caloric tests, MRI of the internal auditory canals) confirming the diagnosis and showing that they are otherwise healthy, and motivation and ability to undergo implantation surgery and to participate in device activation continuous device use for 3 months, device activation, and quarterly monitoring visits until a year after surgery.

Study Status: Recruiting
Study Results Expected: Jan. 01, 2018 |
Sponsor: NIH-NIDCD, John Hopkins School of Medicine; Labyrinth Devices, LLC
Collaborators:
Contact Info: Study Coordinators Carolina Treviño and Kelly Lane (401) 955-7876 [email protected]

More Information and an application to participate can be accessed via the Vestibular Implant Trial link at www.jhu.ed/vnel

Location: Johns Hopkins Vestiblar NeuroEngineering Lab; Baltimore, Maryland USA
NCT Number: NCT02725463
E-Mail: [email protected]


Title: Clinical Trial of the PoNS device for patients with chronic balance
deficits due to mild/mod TBI

Objective: To assess the efficacy of the PoNS device + physical training for improving balance and gait in patients who experienced TBI.

Inclusion Criteria: Subjects must meet all of the following criteria to be
included in the study:
1.      18 to 65 years of age, inclusive, at the time of screening.
2.      Documentation on qualifying TBI (defined as closed-head, non-penetrating,
blunt, whiplash, or explosive blast-induced brain injury) severity (at time
of injury): Glasgow Coma Scale (GCS) score 9-15, with loss of consciousness <
24 hours, post-traumatic amnesia ≤7 days, or hospital admission ≤ 7 days
post-TBI, as determined from medical records.  The study investigator will
ascertain whether the prior medical records are sufficiently detailed.
3.      If female, the subject is not pregnant, not breastfeeding, and has a
negative pregnancy test prior to receipt of the PoNS device
–       Note: Pregnancy testing will be repeated at end-of-study (EOS) (i.e., end
of at-home period).
4.      If female of childbearing potential, the subject agrees to use adequate
contraception from screening and throughout the study period.
A female of non-childbearing potential is defined as a subject who is
postmenopausal (continuous amenorrhea for 12 months) or surgically sterile
(defined as bilateral tubal ligation, bilateral oophorectomy, or
hysterectomy).
5.      At least 1 year post most recent TBI at the time of screening.
6.      Stable neurologic status, as determined from subject’s medical records
and the study physician’s opinion based on no new or changing symptoms.
7.      All candidates will have participated in a focused physical rehabilitation
program for their TBI and have been deemed by their treating
clinician/themselves to have reached a plateau.
8.      Ambulatory and able to walk continuously on a treadmill, level grade (no
inclination) at any speed for 20 minutes, with support if needed.
9.      Access to a treadmill and commitment to utilize this for the at-home
portion of the study;
–       Note: Access is defined as the availability of a treadmill for that
portion of the balance training at (1) the subject’s own home, (2) the home
of a relative/friend, (3) a gym or fitness center, or (4) a wellness facility
associated with the clinical site.
–       If the participant does not currently have access to a treadmill, the
study will provide membership to the OHSU March Wellness Center
10.     Able to understand the study procedures and give informed consent.
11.     Willing and able to adhere to the study schedule.

The study is 6 to 7 weeks long and includes a 5-week physical therapy training program.  Research personnel will provide training and assistance during the study.  This is a research study, not treatment.  Compensation will be provided for qualified participants: You will receive $1500 if you complete the entire study.  If you should leave the study early for any reason, you will be paid for the visits you complete in full.          

Study Status: Recruiting
Study Results Expected: Jan. 02, 2017
Sponsor: Helius Medical Technologies
Contact Info: For information about this study, contact Dr. Sarah Theodoroff at 503-220-8262 ext 51948
Location: Portland, Oregon
E-Mail: [email protected]


Title: Otonomy Meniere's Disease Phase 3

Objective: The Meniere's disease research study is evaluating the safety and effectiveness of an investigational drug for Meniere's disease

Participant Information: Study Volunteers Must:

  • Be between the ages of 18 and 85
  • Be diagnosed with unilateral (one ear only) Meniere's disease
  • Have documented hearing loss

Other criteria apply

Study Status: Recruiting
Study Results Expected: Dec. 31, 2016
Sponsor: Otonomy
Collaborators: CSSi
Contact Info: For more information and to see if you may qualify, call 1-888-205-5801 or visit www.OtonomyResearch.com.
Location: Nationwide
NCT Number: E-Mail: [email protected]

Title: A new diagnostic test to measure vestibular function

Objective: Validate a novel method to measure the extent of loss of vestibular function.

Participant Information: We are recruiting a limited number of patients with either bilateral (both sides) or unilateral (one side) loss of vestibular function. Participants wear a pair of goggles and keep head in the upright position and then tilted to each shoulder for a few minutes. As part of this study you will also have vestibular evoked myogenic potentials (VEMP), a standard test used to evaluate vestibular function. You will be compensated for your time for participating in this study. Costs for parking at the Johns Hopkins Outpatient Center Garage will be covered.

Location: Johns Hopkins, Baltimore, MD.

Contact: Please email [email protected] or phone 410-955-3319 for more information or submitting medical records.


Safety, Tolerability and Efficacy for CGF166 in Patients With Bilateral Severe-to-profound Hearing Loss

Purpose: The goal of the current study is to evaluate the safety, tolerability, and the potential ability of CGF166 delivered through IL-infusion to improve hearing and vestibular function. CGF166 is a recombinant adenovirus 5 (Ad5) vector containing a cDNA encoding the human Atonal transcription factor (Hath1).

Location: Kansas City, KS; Baltimore, MD; New York, NY. Read more


 

Why is vision stable during walking?

Purpose: Objective:To identify a novel and practical means of assessing vestibular function during a functional task 
Participant Information:13 Individuals with vestibulopathy (bilateral vestibular loss) and 13 healthy individuals are being recruited for this study. 
Walking portions of this study (~1 hour including set up) will be conducted at the gait and motion analysis lab at Kennedy Kreiger Institute and the portion of the study involving sitting on a motion platform (~2.5 hours) will be conducted in room 710 in the Ross Building.  Any vestibular function testing will be conducted in The Johns Hopkins Outpatient Center, Department of Otolaryngology.
For participating in this study you will be compensated $50.  Costs for parking at the Johns Hopkins Outpatient Center Garage will be covered.

 

Genetic Analysis of Hereditary Disorders of Hearing and Balance

Purpose: To identify the genetic causes of hereditary hearing loss or balance disorders.
Location: Bethesda, MD. Read more

 

Clinical and Molecular Analysis of Enlarged Vestibular Aqueducts

Purpose: To identify and understand the genetic factors that lead to enlarged vestibular aqueducts
Location: Bethesda, MD. Read more

 

Studies of Vestibular Loss

Purpose: To seek persons with confirmed bilateral vestibular loss to participate in one or more research studies of human balance function. Location: Portland, Oregon. Contact by e-mail.

Search for other vestibular research studies here.

Did this information help you? 

Please consider making a donation to help other vestibular patients find help and hope.

Donate No, thanks